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The medical mechanism of cannabinoids

Recent biochemical shows, that the human body produce cannabinoids  biotransmiters and have a so-called cannabinoid metabolism at the cellular level.

Hanf Transmitter Gehirn

Endocannabinoid System (ECS)

The endocannabinoid system consists of cannabinoid receptors, endocannabinoids, as well as synthesizing and degradative enzymes. It constitutes a highly complex and extremely important physiological system that influences a number of metabolic processes.

The primary functions of ECS appear to be maintaining the body’s homeostasis and teaching the body to recover from stress. They are also effective in the endocannabinoids in different regulatory systems and, for example, reduce blood pressure, body temperature, pain and fear perception, regulate muscle tension and stimulus conduction in the brain and stimulate appetite and reward-behavior.

With the discovery of the two cannabinoid receptors, CB1 and CB2, the molecular basis for the effectiveness of Δ9-THC was explained and the existence of an endogenous cannabinoid system was postulated for the first time. CB1 receptors are present in many areas of the central nervous system (CNS) in high densities and are among the most common G-protein-coupled receptors in the brain. They are also found in various peripheral organs (spleen, stomach, spinal cord, lungs, etc.) to a lesser extent.

CB2 receptors are predominantly expressed by cells in the immune system and are traceable at low-density levels in the brain (microglia, the brain stem) and in the keratinocytes of the skin. Like the CB1 receptors, they also belong to the G-protein-coupled receptors. When they are activated a signaling cascade is set into motion (inhibition of adenylate cyclase, intracellular calcium release, inhibition of the potassium efflux), which eventually leads to a modulation of neuronal excitability.

The medical application spectrum of cannabinoids


This knowledge is now also the key for a deeper understanding of why cannabinoids have such enormous, wide-ranging healing effects. These regulate exactly the cell metabolism. In the recently published book by Dr. med. Franjo Grotenhermen, "Cannabidiol - CBD a cannabis-containing Compendium" the various cannabinoids are introduced and the medical benefits are presented in detail. A brief overview of the various areas of application: epilepsy, anxiety disorders and posttraumatic stress disorders, schizophrenia, inflammation, pain, cancer, dystonia and dyskinesia, dependency and withdrawal, appetite and overweight, Alzheimer's disease, Parkinson's disease, hepatitis, hepatic and brain damage, blood poisoning, bone healing, skin diseases, allergies and asthma, as well as malaria.
Strikingly good results are reported with the Tourette symdrome, as well as with rheumatism, arthritis and various autoimmune diseases.
Even small doses of CBD in the mg range show excellent effects.


Cosmetic use

Hanf-Flaschen-Medizinische Verwendung

From the present medical investigations one could make use among other things the anti-inflammatory, pain-relieving, circulation-promoting, nerve regenerating and cancer-reducing effect by the application on the skin. CB2 receptors are predominantly expressed by cells in the immune system and in the keratinocytes of the skin. So absorbtion via the skin, CBD passes directly into the blood circulation without passing through the digestive system and would therefore be an interesting application variant alone. More and more skin care products with CBD are gradually being offered to the market. This field of application still has great potential, both medically and cosmetically.

Generation and extraction of CBD

The cannabinoids are not water-soluble, but fat-soluble, and have traditionally been triggered with various solvents from the flowers, whereby it is always a fundamental problem to remove the solvents again after the extraction without residues.


Thanks to modern high-pressure technology, CO2 extraction has become established in recent years and has become a standard today. The natural CO2, which is extracted from the air.. Even at a temperature of 66 - 68 ° C and high pressure, the cannabinoids dissolve from the flowers and can be sucked off.

The resulting solvent-free product has a CBD concentration usually between 10 and 20% CBD. The extract is a green pasty mass which, in addition to CBD, also contains various resins of the flowers. From the point of view of bioavailability, it is questionable whether these natural components are to be filtered off. If desired, the varios resind can be filtered awai, to get an golden and more liquid extract. To get a desired concentration CBD is re-diluted mostly with hempseed oil.

CO2 extraction of hemp flowers for CBD extraction

CO2 is liquefied under the influence of pressure and heat (flow sheet left bottom) and is thus a good solvent, the so-called supercritical CO2, for the cannabinoids contained in the hemp blossoms. These are suctioned off at the top and heated again in the second heat exchanger. In the separator 1, the first fraction is then separated. This process is repeated in separator 2. The CO2 is recovered in the condenser and available for a new circle.

The advantages of CO2 extraction:

    • It is not toxic
    • Application medicine and food production
    • Our high-quality biological raw materials are preserved in their natural form
    • It does not leave any harmful residues
    • Free from impurities
    • CO2 is freely available, also in large quantities
    • It is recovered and reused in the circuit
    • Environmentally friendly
    • It is antibacterial and takes place with the exclusion of oxygen

CBD products

CBD is offered and traded in the various processing stages on the market.

Farm fresh, dried flowers for extraction
These flowers are cleansed, free from stalks and seeds and ready processed for extraction

Roh extracts in various concentrations
4 %
10-12 %, green or also as a decarboxylated, gold-colored extract
15-17 %
18 – 20 %
Isolates in a concentration of 99.8% CBD.

As  food technologist and specialist in product development, production and sale of CBD - cannabidiol-containing products, Besthemp offers only the highest quality, beginning from controlled cultivation up certified processing’s. All steps are under strong laboratory control to get the best, possible quality. Our focus is B2B.

We are always keen to maintain the quality of our high-quality raw materials, which are used for intermediate products or for dietary and / or medical purposes.

We are always working to constantly improve product quality and to develop new products. We never lose sight of our goal of offering the market the best possible raw product with a good CBD concentration.

Our Besthemp CBD oil from the CO2 extraction system receives the full spectrum of cannabinoids, thermometers, flavonoids and phenols from EU-certified hemp. Our extracts contain not only CBD, but also cannabinoids, such as mainly CBC, CBG, and CBN. The most frequently occurring components in our Besthemp extracts are myrcene, beta-caryophyllene, linalool, alpha-pinene, beta-pinene, trans-alpha bergamot and alpha-humulen.

In contrast to marijuana, industrial mash is the ideal raw material for CBD production, since it contains some CBD, and almost no THC (less than 0.2%). The ongoing quality controls during the entire processing process guarantee our customers a consistently high quality.

Finished products for application include massage oils, capsules, concentrates and cosmetic care products.

Quality criteria and purchasing recommendations

The quality begins with the preparation of the fields and the seed. Here, the customer can already distinguish whether he attaches importance to bio-certified hemp or whether conventionally grown hemp also meets his needs. It should be noted that our non-certified products are also produced without the use of harmful pesticides and chemicals. All Besthemp-CBD-Extractions are made from biologically certified hemp only.

The further cleaning and processing process of the hemp blossoms is constantly under our strict quality criteria. Only the best equipment and the most advanced technique is used for extraction. The entire  process is constantly monitored by our laboratory, so that only the best and purest qualities are offered. The CBD content of our products is also tested and confirmed by independent laboratories.